麻豆传媒

This new grant program supports the next generation of clinical pharmacologists by funding innovative, human-based research and providing education in key areas such as research, grant writing and grant management.

The grant application process followed the National Institutes of Health’s grant scoring system, using a 9-point rating scale to assess overall impact and individual review criteria. Boleslav’s application stood out for blending methodologies of translational pharmacometrics modeling, targeted metabolomics and multi-omic network analysis to explore interpatient variability in response. He was awarded $25,000 per year for two years.

“It’s an amazing honor to receive this grant,” says Boleslav. “It’s the grant program's first year, and to be one of the two people who are the first recipients is an honor. This grant allows us to further develop the investigative work we have done in the clinic. I think this is also great long-term for my career and will help to provide me with knowledge of effectively managing a grant as well as great opportunities for me to network within the field of clinical pharmacology.”

Boleslav’s current research focuses on understanding pharmacodynamic drug-drug interactions for drug combinations throughout drug development, with the goals of optimizing combination therapy to enhance safety and efficacy. His grant proposal builds upon this research and work done in collaboration with Roswell Park Comprehensive Cancer Center, including an ongoing clinical trial that aims to understand inter-individual variability in response to a novel combination therapy currently in clinical trials. The goal is to identify pharmacodynamic predictors of drug response and predictive biomarkers, ultimately working towards improving personalized medicine strategies. 

“I would like to thank my mentor, Donald Mager, PharmD, PhD, chair and professor, UB Department of Pharmaceutical Sciences, for his support on this project and for encouraging me to pursue this grant, along with our clinical collaborators at Roswell Park: Drs. Christos Fountzilas, Spencer Rosario and Andrei V. Bakin. I also want to thank my lab mates and friends at SPPS, who have been supportive in providing feedback and encouragement throughout this process.”